Exploratory analysis of serum concentrations of oocyte biomarkers growth differentiation factor 9 and bone morphogenetic protein 15 in ovulatory women across the menstrual cycle

ObjectiveTo characterize and evaluate the variation in serum concentrations of oocyte-secreted growth differentiation factor 9 (GDF9) bone morphogenetic protein 15 (BMP15) throughout menstrual cycle women from young to advanced reproductive ages.DesignCross-sectional, observational, exploratory study.SettingMulticenter university-based clinical practices laboratories.Patient(s)Serum was collected every 1–3 days 3 cohorts healthy, ovulatory women: menses late luteal phase (21–29 years age; n = 16; University Otago) across one interovulatory interval (18-35 10; 45–50 15; Saskatchewan).Intervention(s)None.Main Outcome Measure(s)To detect changes GDF9 BMP15 cycle, mean concentration variance were statistically modeled using a generalized additive model location, shape scale (GAMLSS). Follicle-stimulating hormone, luteinizing estradiol, progesterone, anti-Müllerian hormone also assessed.Result(s)GDF9 detectable 54% 73% varied 236-fold 52-fold between women, respectively. Across there minimal or within woman for all cohorts, with no significant differences detected concentrations. However, variances highest phases immediately after ovulation, regardless age.Conclusion(s)Serial not are likewise similar lifespan. Further research is required fully elucidate utility these oocyte biomarkers at diagnosing fertility potential and/or disease. To ages. Cross-sectional, study. Multicenter laboratories. Serum Saskatchewan). None. assessed. age. Serial